An Expert-Informed Introduction to the Elements of Psychedelic-Assisted Therapy provides an overview of the psychedelic-assisted therapy model that is usually employed in clinical research trials of psychedelic med- ications. BrainFutures presents the emerging consensus around best practices for psychedelic-assisted therapy in a clinical context as of fall 2022. These conclusions are informed primarily by interviews and input from 22 experts, including academic researchers, clinical trial investigators, and practitioners. We begin by providing a brief overview of treatment designs that have shown efficacy in academic research including studies associat- ed with FDA-approved clinical trials. In the following chapters, we explore the core elements of psychedelic-as- sisted therapy: screening and assessment, preparation, set and setting, the medication session, and integration. The paper concludes by addressing safety considerations. Each chapter includes a section entitled “The Future of the Field,” which raises questions about how the current model of psychedelic-assisted therapy might be adapted to increase access and/or improve patient outcomes.