KEY POINTS
Perceptions among adolescents regarding hallucinogens use are changing. Current trends show there are increasing emergency department presentations from use of these drugs.
Use of novel hallucinogens, such as 25I-NBOMe, is gaining popularity and can have serious medical complications.
Hallucinogen use may result in psychiatric disorders that may occur at time of use or afterward and may cause secondary psychotic, mood, or anxiety disorders. Limited data exist regarding treatment of these psychiatric disorders in adolescents, and evidence is extrapolated from adult studies. Benzodiazepines and behavioral techniques are recommended first-line treatments. Certain antipsychotics may worsen hallucinogen disorders and should be used with caution.