The consumption of 5-MeO-DMT by inhaling bufotoxins from the Colorado River toad (lat. Incilius Alvarius), also known as “Bufo Alvarius”, “El Sapo/Sapito”, “Bufo”, and “Toad”, has become increasingly popular in a variety of underground ceremonial settings in recent years. Furthermore, due to the realization of the potential 5-MeO-DMT holds for therapy it has also become a new interest in psychedelic research. When I started psychedelic research for my dissertation at Maastricht University in fall 2017, there was no research addressing the subjective effects from inhalation of bufotoxins in humans. Thus, I brought it upon myself to investigate this further as the consumption of the so-called “toad-medicine” was booming worldwide. The primary aim of the study was to investigate whether the bufotoxins from the toad, which is known to contain significant amounts of 5-MeO-DMT, as well as other compounds, produces long-lasting changes on affect and thinking style. The second objective was to assess whether the acute and long-term effects of the bufotoxins depend on the degree of ego dissolution and altered states of consciousness that was experienced during the ceremony. The preliminary evidence of this study was presented at the Beyond Psychedelics conference in Prague in June, and the recording of this presentation is now circling around on the web. Even though the study results are very interesting and important to highlight due to the consumption of the “toad-medicine” worldwide, I think it is of equal importance, if not more, to shed light on another side of the story. A side of the story that for once does not focus on humans. This article aims to share information, increase awareness, and stimulate reflection about how the consumption of bufotoxins affect the toad.