Authors Dieter A. Hagenbach and Lucius Werthmüller, close friends of Albert Hofmann, take readers on a journey through Hofmann’s mystical childhood experiences with nature to his chemistry studies with Nobel Prize winner Paul Karrer in Zurich through his discoveries of both LSD and psilocybin at Sandoz; to his adventurous expeditions; to his many years of retirement devoted to philosophy of nature. Hagenbach and Werthmüller document Hofmann’s rich social life including interactions with illustrious writers, artists and thinkers including luminaries like Aldous Huxley, Timothy Leary and Richard Alpert (Ram Dass).
Throughout Mystic Chemist, the authors reveal the eventful history of LSD, and they chronicle Hofmann’s groundbreaking work with the drug that was later featured in the 2022 Netflix documentary series, “How to Change Your Mind.” From the start of his experimentations, Hofmann took a positive view towards LSD-assisted psychotherapy in the treatment of illness, and he maintained that mystical experiences and trips to other worlds of consciousness are the best preparation for the very last journey we all must eventually make. Mystic Chemist: The Life of Albert Hofmann and His Discovery of LSD contains more than 500 photos, illustrations and drawings as well as a foreword by renowned Czech psychiatrist Stanislav Grof.
Albert Hofmann, who died in 2008 aged 102, first synthesized lysergic acid diethylamide (LSD) in 1938, but the results of animal tests were so unremarkable that the chemical was abandoned. Driven by intuition, he synthesized it again in 1943, and serendipitously noticed its profound effects on himself. Although his work produced other important drugs, including methergine, hydergine and dihydroergotamine, it was LSD that shaped his career. After his discovery of LSD’s properties, Hofmann spent years researching sacred plants. He succeeded in isolating and synthesizing the active compounds in the Psilocybe mexicana mushroom, which he named psilocybin and psilocin. During the 60s, Hofmann struck up friendships with personalities such as Aldous Huxley, Gordon Wasson, and Timothy Leary. He continued to work at Sandoz until 1971 when he retired as Director of Research for the Department of Natural Products. He subsequently served as a member of the Nobel Prize Committee, and was nominated by Time magazine as one of the most influential figures of the 20th century. In 2007, Albert Hofmann asked Amanda Feilding if she could publish his Problem Child, and shortly before his death he approved a new and updated translation of his autobiography (first published by McGraw Hill in 1979). It appears here for the first time in print.
LSA is an Ergine closely related to LSD, and Indigenous communities in Mexico have used it since immemorial times.
Psychedelics fell from medical grace nearly half a century ago, but recent activity suggests that some researchers have “high hopes” for their return.1,2 Over 60 years ago, Albert Hofmann at Sandoz Pharmaceutical Laboratories in Switzerland first synthesized lysergic acid diethylamide (LSD) and personally experienced its effects (later described as a voyage into madness or a chemically induced psychosis) in 1943. Hofmann’s drug opened up a new era of hallucinogenic research. Over the next 15 years, more than a thousand articles on the use of LSD appeared in medical and scientific publications. In 1957, that work gave rise to the term “psychedelic” to describe a mind-manifesting response, described by some as an experience that brought to light matters that had previously been part of the unconscious.