Today, there are few places in the United States where it is legal to access psychedelic-assisted therapy outside of clinical trials. But this is starting to change. Ketamine clinics are legal, and, in 2020, Oregon became the first state to legalize supervised psilocybin treatment. Oregon will start accepting applications for psilocybin treatment licenses in 2023, assuming the federal government doesn’t stop it. Several other states may soon follow Oregon’s lead. Regardless of whether psychedelic-assisted therapy is legalized, safety is still an important concern, and patients need to find the right space and therapist for them.