Tripping into Old Age: Can Psychedelics Protect the Aging Brain?

Berkeley, CA – June 8, 2026

Written by Kara Manke for UC Berkeley News

In a new study, UC Berkeley researchers are investigating whether psilocybin can support healthy aging by boosting plasticity in the brains of older adults.

  • A man wearing an eye mask reclines on a couch in a darkened room. Behind him, the wall is illuminated with a circular, rainbow-colored light
  • Two people sit at a table smiling at the camera. Behind them is a painting with blue swirls that are reminiscent of brain matter.
  • Two people sit across from one another in a brightly lit room that is furnished with a comfortable couch and chair and colorful art on the wall.

Can psychedelics help our minds and brains stay healthy as we grow older?

That’s the question posed by a new first-of-its-kind study launched earlier this year at the UC Berkeley Center for the Science of Psychedelics

The study, known as PLASTICITY (Psychedelic Longitudinal Aging Study In Cognitively Healthy Older Adults), is the first psychedelic neuroimaging study specifically focused on older adults. The study will use MRI and other measures to investigate how psilocybin impacts memory, perception, emotion, and brain structure and function in healthy adults between the ages of 60 and 85.

The researchers will test whether psychedelics can enhance neuroplasticity in the brains of healthy older adults, help them regulate their emotions, feel more socially connected, and experience a sense of awe. Previous work has shown that psychedelics can reduce negative mental states like depression, anxiety, stress and rumination, and that these negative mental states may be linked with accelerated aging, said Tyler Toueg, a UC Berkeley doctoral student in neuroscience who co-led the project’s design.

“There’s a lot of overlap between the mental states that psychedelics influence and those associated with successful aging,” Toueg said.

As populations age worldwide, cognitive decline and neurodegenerative diseases such as Alzheimer’s disease are becoming increasingly common, with significant consequences for individuals, families, and health care systems. Given this demographic shift and the rising burden of neurodegenerative disease, there is an urgent need for new strategies to promote successful aging. 

Previous studies in non-human animals have shown that psilocybin increases the number of synaptic connections in the hippocampus and the prefrontal cortex of the brain. If psilocybin has the same effect on the human brain, it could help counteract the structural brain changes associated with aging. 

“One of the things that I am most interested in is seeing whether we can actually measure those potentially beneficial brain changes in older adults,” Toueg said.

While thousands of people have received psilocybin in controlled research settings over the past several decades, older adults have been largely absent from modern psychedelics studies. A 2024 review found that older adults represented only about 1.4% of all participants.

“Older adults have been almost entirely excluded from modern psychedelics research, yet they may stand to benefit significantly from compounds that promote brain plasticity,” said Michael Silver, a professor of optometry and vision science and neuroscience and the faculty director of the Berkeley Center for the Science of Psychedelics. “This study allows us to directly test whether the promising findings from animal models translate to older humans and to generate data that will inform future research on aging, cognition, and mental health.”

In the study, participants will take 1-30 mg of synthetic psilocybin, a compound found in psychedelic mushrooms. The researchers will collect a baseline assessment before each participant’s psychedelic experience. Then, they’ll repeat the assessment one week and one month after the experience to look for changes. 

The assessments will include cognitive, perceptual, and emotion testing, as well as advanced brain imaging. The imaging includes diffusion MRI to measure the microstructure of the hippocampus — a part of the brain involved with memory and learning — and functional MRI to examine brain activity during memory encoding and retrieval. Participants will also undergo measures of visual perception and will complete surveys examining how subjective aspects of the experience relate to longer-term changes in well-being. 

The study will also assess whether psilocybin can lead to sustained increases in vagus nerve activity when participants are experiencing positive emotions, like awe. Because vagus nerve activity is associated with better recovery from stress, it is a possible mechanism that could explain how psilocybin is related to mental health.

“One of the wonderful aspects of doing a study like this at UC Berkeley is that we are able to work with a broad array of experts — including emotion scientists and people who are experts in cognition and aging — to simultaneously study many facets of the enduring effects of the psychedelic experience,” Silver said. 

The interdisciplinary project was designed by Toueg, a Ph.D. candidate in the neuroscience graduate program at Berkeley, along with faculty spanning neuroscience, psychology, and psychiatry: Silver, a leading neuroscientist in the study of the human visual system in the brain; William Jagust, a prominent neuroscientist studying brain aging and Alzheimer’s disease; Dacher Keltner, a renowned psychologist on emotion, awe and well-being; and Brian Anderson, a psychiatrist at both UCSF and Berkeley’s psychedelics center, who is also acting as the medical director for the study.

If you would like to learn more about potentially being a research participant in BCSP neuroscience studies of human subjects, please email BCSPresearchsubjects@berkeley.edu.

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Five takeaways from UC Berkeley’s new survey on psychedelics in society

For new professor, psychedelics and octopuses may hold keys to the human mind

A Neuroscientist Describes Your Brain on Psychedelics in 101 Seconds

Berkeley, CA – May 4, 2026

Written by Kara Manke and Charlotte Khadra for UC Berkeley News

Michael Silver wants to know what your brain looks like on psychedelics. 

From Timothy Leary to Michael Pollan, countless psychologists, journalists and cultural leaders have documented the profound impact psychedelics can have on the human mind. And long before these substances became popularized in Western society, psychoactive plants were a key component in many Indigenous healing practices.

But underneath these mental states is a physical organ — the brain — composed of a tangled web of neurons and other cells that somehow work together to create these transformative experiences. As Silver explains in this 101 in 101 video, scientists still know very little about what exactly is happening inside the brains of people on psychedelics. 

As the director of the BCSP, Silver is leading a team of researchers who are using brain imaging to uncover the “nuts and bolts” of how psychedelics work in the brain.

By collecting “movies” of the brain activity of people on psychedelics, they hope to link changes in brain activity with changes in perception. This detailed, mechanistic understanding of psychedelics and the brain could not only transform how we understand the human mind and consciousness — it could also lead to new and possibly more effective treatments for mental illness. 

“A psychedelic experience in the right therapeutic context can result in enduring, maybe permanent changes in people… there have been studies in the lab environment where the majority of people rated it as one of the most profound and sometimes spiritually meaningful experiences of their lives,” said Silver, a professor of optometry and vision science and of neuroscience at Berkeley. “We believe that this kind of information will eventually be critical for improving well-being in society and reducing suffering.”

Watch more 101 in 101 videos featuring UC Berkeley faculty and experts here.

Putting Ethics and Public Engagement at the Center of Psychedelics Exploration

Participants discuss ethics in psychedelic basic science research at the workshop
Participants discuss ethics in psychedelic basic science research at the workshop.

Berkeley, CA – Dec 16, 2025 — Scientific research is always a reflection of the world around it—our history, our values and our people. That is why researchers must do more than just observe; they must constantly look inward. Integrating ethics means practicing humility and accountability every day. It means asking: Does this work promote equity? Is it mutually beneficial?

This is critical in psychedelic science. As interest in psychedelics explodes, researchers on the cutting edge face unique ethical dilemmas. To move forward responsibly, they must ensure that the excitement for discovery is matched by a commitment to doing right by the community.

The BCSP’s core values inform work at the center. Within basic science, journalism, community-building, applied research and policy, the BCSP’s staff ask questions and support each other as they figure out how ethical and values-driven principles can be integrated directly into their work and the work of others in the field of psychedelic science.

On November 7, 2025, the BCSP and the Kavli Center for Ethics, Science, and the Public gathered 38 participants for a first-of-its-kind workshop designed specifically for psychedelic basic scientists: researchers who investigate the biological mechanisms of action of psychedelics. Organizers hoped to ask, how do diverse perspectives and disciplines shape psychedelic inquiry for basic research? How do incentive structures and operational environments shape research priorities in basic science? How can researchers make sure they’re doing research with communities and not just about them? How might needs, values, and insights from other disciplines and perspectives also shape basic science? How do those in the psychedelic field understand and integrate values such as equity, reciprocity and humility into their work?

“Unlike applied research, basic science research is often oriented towards discovery and foundational knowledge, rather than in direct response to a societal problem,” said Kuranda Morgan, strategy director and civic science fellow at the BCSP, who co-led the workshop alongside Jen Holmberg and Leana King, both neuroscience PhD students and graduate fellows at the Kavli Center for Ethics, Science, and the Public. “So how do we think about ways that neuroscience can be values-led, culturally attuned, and community-responsive when it can feel more upstream from the problems that society is experiencing?”

Being: Reflexivity in Research

How does one’s own disciplines affect them? How does background shape which issues someone is interested in, their methodologies and their audiences?

When talking about values-led work—and inviting lived experiences and community perspectives to influence that work—it’s important to examine one’s own history and training. That’s why the BCSP began the workshop by establishing context. Sylver Quevedo, who is the scientific director and chair of the board of directors for the Open Mind Collective, a faculty member at the UC Berkeley Center for the Science of Psychedelics and a principal investigator in an FDA trial of MDMA-assisted therapy for PTSD, provided theoretical grounding for the day’s discussion, orienting attendees to the strengths of different disciplines, both research that’s driven by the scientific method and research that’s driven by narrative and personal experience.

Next, participants wrote down one of their own values—humility, curiosity and creativity were stand-outs—and considered how it showed up in their work.

Participants shared their values and the ways they show up in their work

Becoming: Exploring psychedelic inquiry through different disciplines

What new opportunities emerge when different ways of knowing work together? What’s the impact of exploring (or not exploring) perspectives from disciplines different from one’s own?

Background, both professional and personal, shapes how researchers approach their work—which is part of why it’s so meaningful to learn from each other’s work in various disciplines. To that end, participants heard from three different speakers about how they view psychedelic inquiry.

Dr. Heather Kuiper, co-founder and director of the Center for Psychedelic Public Health, spoke about how to approach psychedelic inquiry as a public health issue, related to social and community health. If researchers think about psychedelics as potentially improving outcomes, then how can they establish equity within and across the research process?

Dr. Diana Negrín, a geographer and curator with a focus on identity, space and social movements in Latin America and the United States, explored how geographic, historic and sociocultural contexts shape how plant medicines are stewarded and used. As psychedelics continue to become more mainstream, how do researchers acknowledge how their growing popularity shapes the communities and geographies that they come from? How can researchers reflect on the role of their work in changing relationships between communities and the land?

Marlena Robbins, the program coordinator for the Indigenous Student Research Fellowship at the BCSP and a DrPH candidate at UC Berkeley, spoke about Indigenous knowledge as science. How can researchers respect and learn from Indigenous research ethics, including relational accountability, reciprocity, kinship and trust? What is the importance of cultivating a relationship with the plants themselves?

In breakout groups, participants discussed ethical tensions that came up in their work. Then, each group worked through one dilemma: What are the historical contexts, and forms of insight might add to it? What would it look like if the ethical dilemma was addressed, and what would be the adverse effect if it wasn’t?

“We went through the process of collective sense-making: studying a problem, how it manifests, and what it might look like to have it solved, with people who are different from you,” said Morgan. “That builds a cultivated awareness, which can inform how you think about administering a sacrament or diversifying your research study participants.”

Together, workshop attendees brought together those “flowers” to create a garden of ethical dilemmas.

 An example of an ethical dilemma explored in break-out groups
Participants created a garden of ethical dilemmas to learn about how others are navigating tensions in their work

Belonging: Approaches to ethics and engagement

What does it look like to be inclusive in a research practice? What approaches can successfully advance interdisciplinary work?

How others bring their backgrounds to their work can broaden one’s understanding of psychedelic inquiry—and lead to collaboration, both with other researchers and with subjects of research. The organized asked three speakers to discuss engaged medical research and how to pursue interdisciplinary work in the psychedelic field.

Dr. Lea Witowsky, executive director of the Kavli Center for Ethics, Science, and the Public at UC Berkeley, spoke about three projects that bridge science and society: the Kali Center graduate fellowship, which provides graduate students with ethical training; an event that bridged perspectives between the autism community (care-givers and self-advocates) and scientists studying autism; and an art residency focused on visualizing genetic data in textiles.

Dr. Brian Anderson, a psychiatrist at Zuckerberg San Francisco General Hospital and an associate clinical professor at the UCSF School of Medicine, spoke about how he co-designed a study about demoralization from long-term AIDS diagnosis with the community he researched, focusing on increasing connection through group therapy and dealing with trauma that didn’t qualify as PTSD through psilocybin therapy. Anderson shared how conversational spaces like town halls can steer research questions.

Dr. Bryan Howard, a co-founder of Oakland Hyphae, the first industry-recognized psychedelic testing lab, talked about the importance of trials outside of an academic setting to understand the potency and experiences of various psychedelic substances.

Moving forward

At the end of the workshop, participants gathered together to reflect on what they learned and specific actions that they could take to further develop ethical frameworks in their own research.

“The BCSP is really unique, in that we have these different disciplines: journalism, basic science, applied research, and convenings and events,” says Morgan. “Values-led ways of working are at the core of the BCSP’s identity, and we’ll continue thinking about how to imbue engaged practices, right relationship, cultural attunement and values into our work.” The workshop was a meaningful way to have those conversations—and just the beginning.

Rana Freedman Named Communications Director of the UC Berkeley Center for the Science of Psychedelics

Berkeley, CA – Dec 2, 2025 — The UC Berkeley Center for the Science of Psychedelics (BCSP) has named Rana Freedman as its new Executive Director of Communications, a role that will guide the Center’s strategic communications and voice as it continues to advance psychedelic research for the public good.

Freedman brings more than 25 years of experience in communications, marketing and content development across the nonprofit, philanthropic and higher education sectors. Throughout her career, she has worked to amplify mission-driven organizations and translate their priorities into clear, engaging stories. She’s passionate about connecting people to science in ways that inspire understanding and trust, reflecting the BCSP’s values of integrity, transparency, equity, reciprocity and curiosity—principles that inform all its work.

In her new role, Freedman will oversee the BCSP’s communications strategy, strengthening its visibility as a trusted source on the science and cultural understanding of psychedelics.

“We’re excited to welcome Rana to the BCSP,” says Andrea Venezia, Executive Director of the Center. “Her extensive experience and creative vision will elevate our work and help us connect with new audiences seeking thoughtful and balanced information about psychedelics and their potential benefits.”

“I’m thrilled to join the BCSP at such an exciting time,” says Freedman. “As public curiosity about psychedelics grows, the BCSP’s commitment to rigorous science, multidisciplinary inquiry, and open dialogue are more important than ever. I look forward to collaborating with this talented team—and our partners—to help more people understand the research and its potential impact.”

Before joining the BCSP, Freedman served as Director of Digital and Social Media Marketing at the Chan Zuckerberg Initiative, where she led a team in translating cutting-edge science and AI through digital storytelling. She also spent nearly a decade at the University of California Office of the President, leading integrated marketing strategies that highlighted the University’s research, public service and impact across California and beyond.

Freedman earned her B.A. in religion from Oberlin College.

For media requests for the BCSP, contact Rana at 510-664-5938 or BCSPmedia@berkeley.edu.

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